COPD and related pulmonary diseases
Chronic obstructive pulmonary disease (COPD), strongly associated with cigarette smoking, is one of the leading causes of chronic morbidity and mortality around the world. Since COPD is a heterogenous disease representing different phenotypes from airway obstruction to emphysema, its exact pathogenic mechanisms are still poorly understood. Current COPD diagnosis is based mainly on pulmonary function tests. This results in often late disease detection. Specific biomarkers which differentiate COPD from related diseases could significantly improve treatment and health outcomes.
Our research targets at the further elucidation of the pathological mechanisms connected to smoking and COPD. The major goal is the detection and validation of new diagnostic factors which allow early detection and differentiation of COPD from related diseases. So far several proteins related to smoking and COPD have been detected by a non-biased proteomic screening (two-dimensional gel electrophoresis, 2-DE) and selected proteins including e.g. SP-A have been further characterized.
Last updated: 28.10.2016