Compartmentalization of growth factor signaling in vascular endothelial cells
The growth of blood vessels is an essential biological process during embryonic development. On the other hand, aberrant growth and altered functions of the vasculature are involved in many common diseases. The extracellular matrix (ECM) surrounding the vessels and accompanying stromal cells have important roles providing the structural support and supplying factors that regulate endothelial cell functions. In this project we are interested in signaling pathways that regulate the synthesis and modifications of perivascular ECM constituents and the feedback loops between the ECM, stromal cells and endothelial cells, and how their dysfunctional interactions can lead to vascular diseases. To accomplish our aims we use biochemical, cell biological and tissue culturing models, advanced microscopic imaging and image analysis, as well as genome and system wide mRNA and protein profiling techniques. Cell culture experiments are accompanied by mouse models, and analyses of tissue samples from vascular anomalies.
Last updated: 25.1.2017